Windows API error 5 with "intexmf.exe"

I consistently get this error when running PDFLaTex in MikTex.

initexmf.exe: Windows API error 5: Access is denied. initexmf.exe: Data: C:\ miktex-pdftex.exe: The operation failed for some reason. miktex-pdftex.exe: Data: C:\Program Files (x86)\MiKTeX 2.9\miktex\bin\initexmf.exe